Greenville is the seat of Greenville County, in upstate South Carolina, United States. Greenville is the sixth largest city (by population) in the state of South Carolina. One of the principal cities of the Greenville-Mauldin-Easley Metropolitan Statistical Area (MSA), it had a population of 61,782 as of the year of 2009 1. The metropolitan area had an estimated population of 639,617 in 2009.Greenville is the largest city of the Greenville-Spartanburg-Anderson Combined Statistical Area (CSA) which in 2006 had an estimated population of 1,203,795, making it the largest MSA in the state of South Carolina. The CSA, an 8-county region of northwestern South Carolina, is known as "The Upstate". Greenville is located approximately halfway between Atlanta, Georgia and Charlotte, North Carolina along Interstate 85, and its metropolitan area also includes Interstates 185 and 385.

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