Winston-Salem is a city in the U.S. state of North Carolina, with a 2010 population of 229,617. Winston-Salem is the county seat and largest city of Forsyth County and the fourth-largest city in the state (though a 2011 estimate of Census Bureau estimate of 232,385 makes Winston-Salem fifth largest). Winston-Salem is the second largest municipality in the Piedmont Triad region and is home to the tallest office building in the region, 100 North Main Street, formerly the Wachovia Building and now known locally as the Wells Fargo Center. Winston-Salem is called the "Twin City" for its dual heritage and "City of the Arts and Innovation" for its dedication to fine arts and theater and technological research. "Camel City" is a reference to the city's historic involvement in the tobacco industry related to locally-based R. J. Reynolds Tobacco Company's popular Camel cigarettes. Many locals refer to the city as "Winston" in informal speech.

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